Regions of developing, unmineralized bone ( osteoid ) may expand and encroach on the marrow space, resulting in myelophthisic anemia.
2.
First, when dead bone abuts live marrow, capillaries and undifferentiated mesenchymal cells grow into the dead marrow spaces, while macrophages degrade dead cellular and fat debris.
3.
Although the procedure is called a transplant, the marrow or cord blood is really dripped into a vein like a tranfusion, and the stem cells find their way to the marrow spaces in the patient's bones.
4.
As we infuse these cord blood stem cells, the stem cells will find their way to the empty bone marrow spaces and then begin to multiply and produce and eventually make all the blood cells she needs to survive,
5.
Upon reperfusion, repair of ischemic bone occurs in 2 phases; First, there is angiogenesis and movement of undifferentiated mesenchymal cells from adjacent living bone tissue grow into the dead marrow spaces, as well as entry of macrophages that degrade dead cellular and fat debris.
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